Low Barrier Hydrogen Bonds: Getting Close, but Not Sharing...
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چکیده
منابع مشابه
Low Barrier Hydrogen Bonds: Getting Close, but Not Sharing...
Hydrogen bonding represents one of the primary interactions controlling chemical structure and reactivity. The properties of H-bonds are predicted to vary with the distance between the H-donor and H-acceptor, Figure 1, from a canonical structure (>2.5 Å, Figure 1A), in which the proton resides within a double welled structure, to one in which the proton has become fully delocalized within a sin...
متن کاملStrong, low-barrier hydrogen bonds may be available to enzymes.
The debate over the possible role of strong, low-barrier hydrogen bonds in stabilizing reaction intermediates at enzyme active sites has taken place in the absence of an awareness of the upper limits to the strengths of low-barrier hydrogen bonds involving amino acid side chains. Hydrogen bonds exhibit their maximal strengths in isolation, i.e., in the gas phase. In this work, we measured the i...
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The most recent European Society of Cardiology (ESC) guidelines recommend primary percutaneous coronary intervention (PCI) as the preferred treatment for ST-segment elevation myocardial infarction (STEMI) whenever it is available within 90–120 min of the first medical contact [1]. However, timing of symptom onset appears to be hard to adjudicate precisely, and 'ischaemic time' thereby usually e...
متن کاملCohesion, but not too close
After DNA replication in eukaryotes, the daughter chromatids remain connected throughout G2 and mitosis until they separate in anaphase. In budding yeast, the chromosomal cohesin complex has been shown to bind the chromatids together tightly at multiple points approximately every 10 kb along their entire length. What happens in human cells? Are sister chromatids also bound along their entire le...
متن کاملOn the electronic nature of low-barrier hydrogen bonds in enzymatic reactions.
The electronic nature of low-barrier hydrogen bonds (LBHBs) in enzymatic reactions is discussed based on combined low temperature neutron and x-ray diffraction experiments and on high level ab initio calculations by using the model substrate benzoylacetone. This molecule has a LBHB, as the intramolecular hydrogen bond is described by a double-well potential with a small barrier for hydrogen tra...
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ژورنال
عنوان ژورنال: ACS Central Science
سال: 2015
ISSN: 2374-7943,2374-7951
DOI: 10.1021/acscentsci.5b00215